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Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse.

Journal of toxicologic pathology

Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, Ward JM.
PMID: 26973378
J Toxicol Pathol. 2016;29(1):1S-125S. doi: 10.1293/tox.29.1S. Epub 2016 Feb 13.

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to...

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Nolte T, Brander-Weber P, Dangler C, et al. Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse. J Toxicol Pathol. 2016;29(1):1S-125Sdoi: 10.1293/tox.29.1S.
Nolte, T., Brander-Weber, P., Dangler, C., Deschl, U., Elwell, M. R., Greaves, P., Hailey, R., Leach, M. W., Pandiri, A. R., Rogers, A., Shackelford, C. C., Spencer, A., Tanaka, T., & Ward, J. M. (2016). Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse. Journal of toxicologic pathology, 29(1), 1S-125S. https://doi.org/10.1293/tox.29.1S
Nolte, Thomas, et al. "Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse." Journal of toxicologic pathology vol. 29,1 (2016): 1S-125S. doi: https://doi.org/10.1293/tox.29.1S
Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, Ward JM. Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse. J Toxicol Pathol. 2016;29(1):1S-125S. doi: 10.1293/tox.29.1S. Epub 2016 Feb 13. PMID: 26973378; PMCID: PMC4765498.
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Effects of cadmium exposure on Iberian ribbed newt (.

Journal of toxicologic pathology

Hirako A, Takeoka Y, Hayashi T, Takeuchi T, Furukawa S, Sugiyama A.
PMID: 29097846
J Toxicol Pathol. 2017 Oct;30(4):345-350. doi: 10.1293/tox.2017-0032. Epub 2017 Jul 23.

To characterize the histomorphologic effects of cadmium on adult newt testes, male Iberian ribbed newts (6 months post-hatching) were intraperitoneally exposed to a single dose of 50 mg/kg of cadmium, with histologic analysis of the testes at 24, 48,...

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Hirako A, Takeoka Y, Hayashi T, et al. Effects of cadmium exposure on Iberian ribbed newt (. J Toxicol Pathol. 2017;30(4):345-350doi: 10.1293/tox.2017-0032.
Hirako, A., Takeoka, Y., Hayashi, T., Takeuchi, T., Furukawa, S., & Sugiyama, A. (2017). Effects of cadmium exposure on Iberian ribbed newt (. Journal of toxicologic pathology, 30(4), 345-350. https://doi.org/10.1293/tox.2017-0032
Hirako, Ayano, et al. "Effects of cadmium exposure on Iberian ribbed newt (." Journal of toxicologic pathology vol. 30,4 (2017): 345-350. doi: https://doi.org/10.1293/tox.2017-0032
Hirako A, Takeoka Y, Hayashi T, Takeuchi T, Furukawa S, Sugiyama A. Effects of cadmium exposure on Iberian ribbed newt (. J Toxicol Pathol. 2017 Oct;30(4):345-350. doi: 10.1293/tox.2017-0032. Epub 2017 Jul 23. PMID: 29097846; PMCID: PMC5660958.
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MicroRNAs associated with the development of kidney diseases in humans and animals.

Journal of toxicologic pathology

Ichii O, Horino T.
PMID: 29479137
J Toxicol Pathol. 2018 Jan;31(1):23-34. doi: 10.1293/tox.2017-0051. Epub 2017 Oct 06.

Mature microRNAs (miRNAs) are single-stranded RNAs with approximately 18-25 bases, and their sequences are highly conserved among animals. miRNAs act as posttranscriptional regulators by binding mRNAs, and their main function involves the degradation of their target mRNAs. Recent studies...

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Ichii O, Horino T. MicroRNAs associated with the development of kidney diseases in humans and animals. J Toxicol Pathol. 2017;31(1):23-34doi: 10.1293/tox.2017-0051.
Ichii, O., & Horino, T. (2018). MicroRNAs associated with the development of kidney diseases in humans and animals. Journal of toxicologic pathology, 31(1), 23-34. https://doi.org/10.1293/tox.2017-0051
Ichii, Osamu, and Horino, Taro. "MicroRNAs associated with the development of kidney diseases in humans and animals." Journal of toxicologic pathology vol. 31,1 (2018): 23-34. doi: https://doi.org/10.1293/tox.2017-0051
Ichii O, Horino T. MicroRNAs associated with the development of kidney diseases in humans and animals. J Toxicol Pathol. 2018 Jan;31(1):23-34. doi: 10.1293/tox.2017-0051. Epub 2017 Oct 06. PMID: 29479137; PMCID: PMC5820100.
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Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay.

Journal of toxicologic pathology

Furukawa M, Sakakibara T, Itoh K, Kawamura K, Sasaki S, Matsuura M.
PMID: 26538816
J Toxicol Pathol. 2015 Oct;28(4):243-8. doi: 10.1293/tox.2015-0022. Epub 2015 Jul 31.

The bovine corneal opacity and permeability (BCOP) assay is an alternative method to the in vivo Draize eye test in rabbits for evaluating eye irritation in vitro. Here, we compared the numerical results of the BCOP assay with the...

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Furukawa M, Sakakibara T, Itoh K, et al. Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay. J Toxicol Pathol. 2015;28(4):243-8doi: 10.1293/tox.2015-0022.
Furukawa, M., Sakakibara, T., Itoh, K., Kawamura, K., Sasaki, S., & Matsuura, M. (2015). Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay. Journal of toxicologic pathology, 28(4), 243-8. https://doi.org/10.1293/tox.2015-0022
Furukawa, Masatoshi, et al. "Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay." Journal of toxicologic pathology vol. 28,4 (2015): 243-8. doi: https://doi.org/10.1293/tox.2015-0022
Furukawa M, Sakakibara T, Itoh K, Kawamura K, Sasaki S, Matsuura M. Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay. J Toxicol Pathol. 2015 Oct;28(4):243-8. doi: 10.1293/tox.2015-0022. Epub 2015 Jul 31. PMID: 26538816; PMCID: PMC4604136.
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Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice.

Journal of toxicologic pathology

He XJ, Uchida K, Megumi C, Tsuge N, Nakayama H.
PMID: 26538809
J Toxicol Pathol. 2015 Oct;28(4):197-206. doi: 10.1293/tox.2015-0020. Epub 2015 Jul 27.

Studies in vivo and in vitro suggest that curcumin is a neuroprotective agent. Experiments were conducted to determine whether dietary supplementation with curcumin has neuroprotective effects in a mouse model of Parkinson's disease (PD). Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) significantly...

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He XJ, Uchida K, Megumi C, et al. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. J Toxicol Pathol. 2015;28(4):197-206doi: 10.1293/tox.2015-0020.
He, X. J., Uchida, K., Megumi, C., Tsuge, N., & Nakayama, H. (2015). Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology, 28(4), 197-206. https://doi.org/10.1293/tox.2015-0020
He, Xi-Jun, et al. "Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice." Journal of toxicologic pathology vol. 28,4 (2015): 197-206. doi: https://doi.org/10.1293/tox.2015-0020
He XJ, Uchida K, Megumi C, Tsuge N, Nakayama H. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. J Toxicol Pathol. 2015 Oct;28(4):197-206. doi: 10.1293/tox.2015-0020. Epub 2015 Jul 27. PMID: 26538809; PMCID: PMC4604129.
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A comparison of the histological structure of the placenta in experimental animals.

Journal of toxicologic pathology

Furukawa S, Kuroda Y, Sugiyama A.
PMID: 24791062
J Toxicol Pathol. 2014 Apr;27(1):11-8. doi: 10.1293/tox.2013-0060. Epub 2014 Apr 30.

The primary function of the placenta is to act as an interface between the dam and fetus. The anatomic structure of the chorioallantoic placenta in eutherian mammals varies between different animal species. The placental types in eutherian mammals are...

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Furukawa S, Kuroda Y, Sugiyama A. A comparison of the histological structure of the placenta in experimental animals. J Toxicol Pathol. 2014;27(1):11-8doi: 10.1293/tox.2013-0060.
Furukawa, S., Kuroda, Y., & Sugiyama, A. (2014). A comparison of the histological structure of the placenta in experimental animals. Journal of toxicologic pathology, 27(1), 11-8. https://doi.org/10.1293/tox.2013-0060
Furukawa, Satoshi, et al. "A comparison of the histological structure of the placenta in experimental animals." Journal of toxicologic pathology vol. 27,1 (2014): 11-8. doi: https://doi.org/10.1293/tox.2013-0060
Furukawa S, Kuroda Y, Sugiyama A. A comparison of the histological structure of the placenta in experimental animals. J Toxicol Pathol. 2014 Apr;27(1):11-8. doi: 10.1293/tox.2013-0060. Epub 2014 Apr 30. PMID: 24791062; PMCID: PMC4000068.
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Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis.

Journal of toxicologic pathology

Ohnishi T, Hisaoka F, Morishima M, Takahashi A, Harada N, Mawatari K, Arai H, Yoshioka E, Toda S, Keisuke I, Nakaya Y.
PMID: 24791067
J Toxicol Pathol. 2014 Apr;27(1):51-6. doi: 10.1293/tox.2012-0032. Epub 2014 Apr 30.

Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat - a...

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Ohnishi T, Hisaoka F, Morishima M, et al. Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis. J Toxicol Pathol. 2014;27(1):51-6doi: 10.1293/tox.2012-0032.
Ohnishi, T., Hisaoka, F., Morishima, M., Takahashi, A., Harada, N., Mawatari, K., Arai, H., Yoshioka, E., Toda, S., Keisuke, I., & Nakaya, Y. (2014). Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis. Journal of toxicologic pathology, 27(1), 51-6. https://doi.org/10.1293/tox.2012-0032
Ohnishi, Takamasa, et al. "Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis." Journal of toxicologic pathology vol. 27,1 (2014): 51-6. doi: https://doi.org/10.1293/tox.2012-0032
Ohnishi T, Hisaoka F, Morishima M, Takahashi A, Harada N, Mawatari K, Arai H, Yoshioka E, Toda S, Keisuke I, Nakaya Y. Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis. J Toxicol Pathol. 2014 Apr;27(1):51-6. doi: 10.1293/tox.2012-0032. Epub 2014 Apr 30. PMID: 24791067; PMCID: PMC4000073.
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Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries.

Journal of toxicologic pathology

Anzai T, Kaminishi M, Sato K, Kaufman L, Iwata H, Nakae D.
PMID: 26028814
J Toxicol Pathol. 2015 Apr;28(2):57-64. doi: 10.1293/tox.2015-0007. Epub 2015 Apr 01.

The Standard for the Exchange of Nonclinical Data (SEND), adopted by the US FDA, is part of a set of regulations and guidances requiring the submission of standardized electronic study data for nonclinical and clinical data submissions. SEND is...

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Anzai T, Kaminishi M, Sato K, et al. Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries. J Toxicol Pathol. 2015;28(2):57-64doi: 10.1293/tox.2015-0007.
Anzai, T., Kaminishi, M., Sato, K., Kaufman, L., Iwata, H., & Nakae, D. (2015). Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries. Journal of toxicologic pathology, 28(2), 57-64. https://doi.org/10.1293/tox.2015-0007
Anzai, Takayuki, et al. "Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries." Journal of toxicologic pathology vol. 28,2 (2015): 57-64. doi: https://doi.org/10.1293/tox.2015-0007
Anzai T, Kaminishi M, Sato K, Kaufman L, Iwata H, Nakae D. Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries. J Toxicol Pathol. 2015 Apr;28(2):57-64. doi: 10.1293/tox.2015-0007. Epub 2015 Apr 01. PMID: 26028814; PMCID: PMC4444503.
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Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats.

Journal of toxicologic pathology

Sato M, Todoriki S, Takahashi T, Hafez E, Takasu C, Uehara H, Yamakage K, Kondo T, Matsumoto K, Furuta M, Izumi K.
PMID: 26028819
J Toxicol Pathol. 2015 Apr;28(2):99-107. doi: 10.1293/tox.2015-0002. Epub 2015 Feb 16.

A 90-day oral toxicity test in rats was performed to evaluate the toxicity of 2-tetradecylcyclobutanone (2-tDCB), a unique radiolytic product of stearic acid. Six-week-old male and female F344 rats (n=15/group) were given 2-tDCB at concentrations of 0, 12, 60...

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Sato M, Todoriki S, Takahashi T, et al. Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats. J Toxicol Pathol. 2015;28(2):99-107doi: 10.1293/tox.2015-0002.
Sato, M., Todoriki, S., Takahashi, T., Hafez, E., Takasu, C., Uehara, H., Yamakage, K., Kondo, T., Matsumoto, K., Furuta, M., & Izumi, K. (2015). Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats. Journal of toxicologic pathology, 28(2), 99-107. https://doi.org/10.1293/tox.2015-0002
Sato, Makoto, et al. "Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats." Journal of toxicologic pathology vol. 28,2 (2015): 99-107. doi: https://doi.org/10.1293/tox.2015-0002
Sato M, Todoriki S, Takahashi T, Hafez E, Takasu C, Uehara H, Yamakage K, Kondo T, Matsumoto K, Furuta M, Izumi K. Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats. J Toxicol Pathol. 2015 Apr;28(2):99-107. doi: 10.1293/tox.2015-0002. Epub 2015 Feb 16. PMID: 26028819; PMCID: PMC4444508.
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Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium.

Journal of toxicologic pathology

Sonoda J, Seki Y, Hakura A, Hosokawa S.
PMID: 26028820
J Toxicol Pathol. 2015 Apr;28(2):109-20. doi: 10.1293/tox.2014-0061. Epub 2015 Mar 01.

Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS)...

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Sonoda J, Seki Y, Hakura A, et al. Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium. J Toxicol Pathol. 2015;28(2):109-20doi: 10.1293/tox.2014-0061.
Sonoda, J., Seki, Y., Hakura, A., & Hosokawa, S. (2015). Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium. Journal of toxicologic pathology, 28(2), 109-20. https://doi.org/10.1293/tox.2014-0061
Sonoda, Jiro, et al. "Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium." Journal of toxicologic pathology vol. 28,2 (2015): 109-20. doi: https://doi.org/10.1293/tox.2014-0061
Sonoda J, Seki Y, Hakura A, Hosokawa S. Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium. J Toxicol Pathol. 2015 Apr;28(2):109-20. doi: 10.1293/tox.2014-0061. Epub 2015 Mar 01. PMID: 26028820; PMCID: PMC4444509.
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Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits.

Journal of toxicologic pathology

Yamagiwa Y, Haranosono Y, Nemoto S, Atsumi I, Kurata M, Kito G, Hatakeyama H, Koizumi H, Sakaki H.
PMID: 28458451
J Toxicol Pathol. 2017 Apr;30(2):135-143. doi: 10.1293/tox.2016-0003. Epub 2016 Nov 27.

Several cationic-amphiphilic drugs such as chloroquine and amiodarone are known to induce phospholipidosis in the cornea by systemic administration. However, the characteristics of ophthalmological and pathological changes when phospholipidosis-inducing drugs are topically applied have not been well studied. This...

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Yamagiwa Y, Haranosono Y, Nemoto S, et al. Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits. J Toxicol Pathol. 2016;30(2):135-143doi: 10.1293/tox.2016-0003.
Yamagiwa, Y., Haranosono, Y., Nemoto, S., Atsumi, I., Kurata, M., Kito, G., Hatakeyama, H., Koizumi, H., & Sakaki, H. (2017). Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits. Journal of toxicologic pathology, 30(2), 135-143. https://doi.org/10.1293/tox.2016-0003
Yamagiwa, Yoshinori, et al. "Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits." Journal of toxicologic pathology vol. 30,2 (2017): 135-143. doi: https://doi.org/10.1293/tox.2016-0003
Yamagiwa Y, Haranosono Y, Nemoto S, Atsumi I, Kurata M, Kito G, Hatakeyama H, Koizumi H, Sakaki H. Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits. J Toxicol Pathol. 2017 Apr;30(2):135-143. doi: 10.1293/tox.2016-0003. Epub 2016 Nov 27. PMID: 28458451; PMCID: PMC5406592.
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Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats.

Journal of toxicologic pathology

Ozaki K, Hamano H, Matsuura T, Narama I.
PMID: 26989296
J Toxicol Pathol. 2016 Jan;29(1):1-6. doi: 10.1293/tox.2015-0033. Epub 2015 Sep 20.

The relationship between hypertension and diabetic peripheral neuropathy (DPN) has recently been reported in clinical research, but it remains unclear whether hypertension is a risk factor for DPN. To investigate the effects of hypertension on DPN, we analyzed morphological...

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Ozaki K, Hamano H, Matsuura T, et al. Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats. J Toxicol Pathol. 2015;29(1):1-6doi: 10.1293/tox.2015-0033.
Ozaki, K., Hamano, H., Matsuura, T., & Narama, I. (2016). Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats. Journal of toxicologic pathology, 29(1), 1-6. https://doi.org/10.1293/tox.2015-0033
Ozaki, Kiyokazu, et al. "Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats." Journal of toxicologic pathology vol. 29,1 (2016): 1-6. doi: https://doi.org/10.1293/tox.2015-0033
Ozaki K, Hamano H, Matsuura T, Narama I. Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats. J Toxicol Pathol. 2016 Jan;29(1):1-6. doi: 10.1293/tox.2015-0033. Epub 2015 Sep 20. PMID: 26989296; PMCID: PMC4766525.
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Showing 1 to 12 of 628 entries